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2026
Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence
Allison H. Kao, Biswa P. Mishra , Mitchell Sorbello, Wenbin Zhang, Qinyi Zhou, Yuefeng Jiang, Veronika Masic, Paige Harten, Weixi Gu, Jian Yuan Yang, A. Joseph Bloom, Robi D. Mitra , Zhe Zhang , Yong Juan Zhao , Giuseppe Orsomando , Xiaodong Wang , Jeffrey Milbrandt , Bostjan Kobe , Thomas Ve , and Aaron DiAntonio
Posted September 11, 2026
LTBP isoforms differentially encode TGF-β spatial localization and activation (bioRxiv)
Lixia Wang, Dong Zhou, View ORCID ProfileJie Tan, Xuezhen Lin, View ORCID ProfileXinyu Zhao, Pengqing Yuan, Jizhe Liu, View ORCID ProfileRuxue Li, Niu Wang, Ziying Wang, Fu-Ying Tian, Ying Li, Zhe Zhang, View ORCID ProfileBo Zhao
Posted August 06, 2026
Structural basis for multivitamin recognition and transport by human SMVT (Nature Communications)
Qiuxin Zhen, Mingshuai Wang & Zhe Zhang
June 2026
Combinatorial docking and molecular generation to navigate over 100-billion molecules for prospective ligand discovery (bioRxiv)
Jianxiang Zhang, Chao Yang, Yang Zhang, Xiao Chen, Brandon Lam, Claire Bryant, Shabareesh Pidathala, Yangzhi Wang, Yurii S. Moroz, Dmytro S. Radchenko, Assaf Alon, Chia-Hsueh Lee, Zhe Zhang, Jiankun Lyu
Posted June 11, 2026
2025
Dynamic dissection of NINJ1-mediated plasma membrane rupture reveals a multi-stage process (Research Square)
Fang Jiao, Zhaoyi Zhai, Xue Bai, Bo Yan, Zehao Zhou, Fang Ii, Fang Chen, Xinrui Guo, Jie Chen, Chenguang Yang, James Farriell Chen, Yan Ma, Yang Cao, Zang Cao, Zhen Zhou, Xin Liu, Qiaozhen Kang, Jiling Lu, Ying Li, Mjang Yang, Lijiang Yang, Guanghou Shui, Xun Huang, Men Huaang, Xun Huang, Yi Qin Gao, Youwei Al, Zhe Zhang
posted 10 Nov, 2025
Structural basis of G6P/Pi transport and inhibition in SLC37A4 (Naturestructural & Molecular Biology)
Dong Zhou, Yang Zhang, Nanhao Chen, Shitang Huang, Chen Song, Zhe Zhang
November 2025
Structural basis of VAChT inhibition by spiroindolines and alkylsulfones (Structure)
Yang Zhang, Zhe Zhang
October 2025
Mechanistic insights into the acetyl-CoA recognition by SLC33A1 (Cell Discovery)
Dong Zhou, Nanhao Chen, Shitang Huang, Chen Song &Zhe Zhang
April 2025
Structural basis of human VANGL-PRICKLE interaction (Nature Communications)
Yanyi Song, Shuyi Jian, Junlin Teng, Pengli Zheng, Zhe Zhang
January 2025
2024
A conserved mechanism couples cytosolic domain movements to pore gating in the TRPM2 channel (PNAS)
Balázs Tóth, Yuefeng Jiang, Andras Szollosi, Zhe Zhang and László Csanády
November 2024
Structural insights into VAChT neurotransmitter recognition and inhibition (Cell Research)
Yang Zhang, Fei Dai, Nanhao Chen, Dong Zhou, Chia-Hsueh Lee, Chen Song, Yixiao Zhang & Zhe Zhang
June 2024
Substrate and drug recognition mechanisms of SLC19A3 (Cell Research)
Yu Dang, Tianyi Zhang, Shabareesh Pidathala, Guopeng Wang, Yijie Wang, Nanhao Chen, Chen Song, Chia-Hsueh Lee, Zhe Zhang
March 2024
2023
Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2 (Nature)
Shabareesh Pidathala, Shuyun Liao, Yaxin Dai, Xiao Li, Changkun Long, Chi-Lun Chang, Zhe Zhang& Chia-Hsueh Lee
November 2023
Structure and mechanism of a neuropeptideactivated channel in the ENaC/DEG superfamily (Nature Chemical Biology)
Fenglian Liu, Yu Dang, Lu Li, Hao Feng, Jianlin Li, Haowei Wang, Xu Zhang, Zhe Zhang✉, Sheng Ye✉, Yutao Tian✉ & Qingfeng Chen✉
August 2023
Structure and dynamics of the EGFR/HER2 heterodimer (Cell Discovery)
Xue Bai, Pengyu Sun, Xinghao Wang, Changkun Long, Shuyun Liao, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He & Zhe Zhang
February 2023
2022
Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8 (Nature Communications)
Zelin Duan, Xuezhen Lin, Lixia Wang, Qiuxin Zhen, Yuefeng Jiang, Chuxin Chen, Jing Yang, Chia-Hsueh Lee, Yan Qin, Ying Li, Bo Zhao, Jianchuan Wang & Zhe Zhang
August 2022
Molecular mechanism of substrate recognition by folate transporter SLC19A1 (Cell Discovery)
Yu Dang, Dong Zhou, Xiaojuan Du, Hongtu Zhao, Chia-Hsueh Lee, Jing Yang, Yijie Wang, Changdong Qin, Zhenxi Guo & Zhe Zhang
December 2022
Tuning the Size of Large Dense-Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid–Liquid Phase Separation (Advanced Science)
Zhaohan Lin, Yinglin Li, Yuqi Hang, Changhe Wang, Bing Liu, Jie Li, Lili Yin, Xiaohan Jiang, Xingyu Du, Zhongjun Qiao, Feipeng Zhu, Zhe Zhang, Quanfeng Zhang, Zhuan Zhou
July 2022
